RESEARCH AREA
A. Nucleation Study on Heterogeneous Surface/Template
Self-assembled monolayer:
Self-assembled organic monolayers (SAMs) are ordered molecular assemblies that are formed spontaneously by the adsorption of surfactant/function molecules. Obtain oriented crystallization of a desired polymorph on functional SAM templates is one of the prime objectives of our research group.
Organo-Gels:
Gels are soft matter that entraps solvent in a 3D network of fibers intertwined by probable non-covalent supramolecular interactions. The scope to minimize diffusion and control supersaturation leads to discovery of new polymorph, screening of polymorph and habit modification of different crystalline APIs. We have commenced experiments successfully and achieved control over crystallization behavior of drug compound mediated in organo-gels.
B. Porous Organic Polymer (POP)/Covalent Organic Framework (COF)
POPs are a class of multi-dimensional porous network materials, which are built via strong covalent linkages. COFs are the class of crystalline porous organic polymers with permanent porosity and highly ordered structures. These materials are used in gas adsorption, catalysis, energy storage and to improve charge carrier transport and photoconductive properties of photovoltaic cells. Our research group has been working in the synthesis of such materials for gas absorption and catalysis of important organic transformation reactions.
C. Crystal Engineering of Pharmaceutical Compounds
In pharmaceutical industries, enormous number of drug molecules are found with poor pharmacological properties. Crystal engineering is a proven technology to improve the properties of these active compounds. Pharmaceutical cocrystal/salts, polymorphism etc have gained a tremendous importance because of its ability to fine-tune the properties of the parent drugs. We have demonstrated several case studies of cocrystal/salt synthesis in order to modify the physiochemical properties of the drug.